BDBM2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US20240002365, Compound staurosporine::US9206188, Staurosporine::US9226923, Staurosporine
SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
InChI Key InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 2579
Affinity DataIC50: 10nMpH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptorsubstrate.More data for this Ligand-Target Pair
Affinity DataKd: 1.40nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Average Binding Constant for PIM1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 3.20nMAssay Description:Binding constant for PIM1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3.20nMAssay Description:Binding constant for PIM1 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of Pim1 kinase (unknown origin) using substrate S3 after 50 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human Pim1 expressed in bacterial expression system using histone H1 as substrate after 30 mins by ADP-Glo reagent based lu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of PIM1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human GST-tagged PIM1 by ELISAMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 2579
ITC DataΔG°: -11.5kcal/mole −TΔS°: -3.33kcal/mole ΔH°: -8.09kcal/mole logk: 7.05E+8
pH: 7.5 T: 10.00°C
pH: 7.5 T: 10.00°C